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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T12459 | PI3K/mTOR Inhibitor-2 | PI3K , mTOR | |
PI3K/mTOR Inhibitor-2 is a potent pan inhibitor of PI3K and mTOR with IC50s of 3.4, 34, 16,1 and 4.7 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR. PI3K/mTOR Inhibitor-2 has antitumor activity. | |||
T35343 | MTI-31 | MTI-31,LXI-15029 | mTOR |
MTI-31 (LXI-15029) is a potent, orally active and highly selective inhibitor of mTORC1 and mTORC2. MTI-31 is selective for mTOR (Kd: 0.20 nM) versus PIK3CA, PIK3CB and PIK3G with >5,000 fold selectivity in mTOR binding a... | |||
T6100 | Torin 2 | Apoptosis , ATM/ATR , DNA-PK , mTOR , Autophagy | |
Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic properties. The EC50 of Torin 2 for ATM/ATR/DNA-PK inhibition is 2... | |||
T7343 | PF-04979064 | PI3K , mTOR | |
PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively). | |||
T7166 | GNE-493 | PI3K , mTOR | |
GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR,respectively. | |||
T6557 | KU-0060648 | KU0060648 | DNA-PK , PI3K , mTOR |
KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ with IC50 of 0.59 μM. | |||
T16355 | NSC781406 | PI3K , mTOR | |
NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα). | |||
T25399 | ETP-45658 | ETP45658,ETP 45658 | DNA-PK , PI3K , mTOR |
ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively). Also inhibits DNA-PK and mTOR (IC50 values are 70.6 and 152 nM respectively... | |||
T16567 | PQR530 | PQR-530 | PI3K , mTOR |
PQR530 is a highly potent dual pan-PI3K/mTORC1/2 inhibitor. PQR530 inhibited protein kinase B (PKB, pSer473) and ribosomal protein S6 (pS6, pSer235/236) phosphorylation with IC50 values of 0.07 μM. It also showing antitu... | |||
T6845 | GNE-317 | GNE317 | PI3K , mTOR |
GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB). | |||
T6143 | PI-103 | PI103,PI 103 | Apoptosis , DNA-PK , PI3K , mTOR , Autophagy |
PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK). | |||
T3692 | GNE-477 | GNE 477 | PI3K , mTOR |
GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor. | |||
T1967 | AZD-3463 | ALK/IGF1R inhibitor | Apoptosis , IGF-1R , ALK , Autophagy |
AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency. | |||
T4199 | Desmethyl-VS-5584 | PI3K , mTOR | |
Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer. | |||
T3541 | CC-115 | CC 115 | DNA-PK , PI3K , mTOR |
CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM). | |||
T36083 | DS-7423 | PI3K , mTOR | |
DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR, respectively. DS-7423 possesses anti-tumor activity[1][2]. DS-7423 increases TP53 expression, the level of p-TP53 on Ser... | |||
TN1405 | Arnicolide D | Akt , Caspase , PI3K , STAT , mTOR | |
Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling path... | |||
T2357 | GSK1059615 | GSK 1059615,GSK-1059615 | Apoptosis , PI3K , mTOR |
GSK1059615 has been used in trials studying the treatment of Lymphoma, Solid Tumours, Endometrial Cancer, Solid Tumor Cancer, and Metastatic Breast Cancer. | |||
T22339 | GNE-490 | Others , PI3K | |
GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively. GNE-490 has >200 fold selectivity for mTOR (IC50 = 750 nM). | |||
T6251 | PF-04691502 | PF4691502 | Akt , PI3K , mTOR , Autophagy |
PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity. |